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Cascio G, Manghisi E, Porta R, Fregnan G. 
“N-phenylpiperazine derivatives with hypocholesterolemic activity”. 
J Med Chem. 1985 Jun 29;28(6):815-8.
A series of new 4-4-phenyl-1-piperazinyl-1-4-fluorophenyl-2-acyloxy-1-butanones and 4-aryl-5-[omega-4-aryl-1-piperazinylalkyl]-1,3-dioxol-2-ones were synthesized and tested preliminarily for hypolipemic activity. Plasma cholesterol-lowering activity in normal rats was found especially in several dioxolones, two of the most active compounds 6 and 8 being more potent than clofibrate. 4-4-Chlorophenyl-5-[2-4-phenyl-1-piperazinylethyl]-1,3-dioxol- 2-one 8, LR-19,731 has been selected for clinical trials.
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