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Zhang CX, Ge ZM, Cheng TM, Li RT. 
“Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594”. 
Bioorg Med Chem Lett. 2006 Apr 27;16(7):2013-6.
Abstract
A series of highly sterically hindered secondary amine analogues of pyridylmethylamine 7a-f, 8a-c and positional isomeric analogues of ABT-594 9a-c were synthesized and evaluated for their in vivo analgesic activity. The compounds 7a and 7d show potent analgesic activity and lower toxicity. Some interesting structure-activity relationships have been revealed.
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