Erowid References Database
Bertilsson L, Koslow SH, Costa E.
“5-Hydroxytryptamine depletion in mesencephalic nuclei of rat brain following a single injection of p-chloroamphetamine”.
Brain Res. 1975 Jun 11;91(2):348-50.
A single dose of p-chloroamphetamine PCA reduces the content of 5-hydroxytryptamine
5-HT and 5-hydroxyindoleacetic acid, the turnover rate of 5-HT and
the activity of tryptophan-5-hydroxylase in rat brain for several months3,5,11,12. It
has been suggested that this long lasting deficit is due to a neurotoxic effect, possibly
mediated through a not yet identified epoxide or hydroxylamine metabolite of PCA5,12
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