Erowid References Database
Ardis AE, Baltzly R, Schoen W.
“Amines Related to 2,5-Dimethoxyphenethylamine. 111 2-Hydroxy and 2-Methoxy-5-methylphenylalkanolamines”.
Journal of American Chemical Society. 1946 Apr;68(4):591-5.
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Abstract
Pharmacological studies of the substances reported in the earlier papers of this series having shown that considerable value as pressors is exhibited by the primary and secondary β-hydroxy-β- (2,5-dimethoxy)-phenylethyl and phenylisopropylamines,
it was of interest to compare these with the analogous substances in which the 5-
methoxyl group was exchanged for a methyl group. At the same time the preparation of 2-hydroxy-5-methyl analogs by using the benzyl group for protection proved to be feasible although offering some experimental difficulties in the earlier part of the work.
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