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Journal of the American Chemistry Society. 1932 Jan 07;54(1):271-4.
In a previous paper' it was demonstrated with dl-&946-phenylisopropylamine that the introduction of a methyl group into the side chain of &946-phenylethylamine furnishes a compound differing from the latter with regard to certain of its effects when administered as a drug compound. The dl-P-phenylisopropylamine exerts a pressor effect for a longer period of time and is quite effective after oral administration. Because of the very considerable importance of developing drug compounds of this general type that are active after oral administration, it seemed important to study some derivatives of dl-&946-phenylisopropylamine having one or more hydroxyl groups introduced into the benzene ring.
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