Erowid References Database
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Alberico D, Rudolph A, Lautens M.
“Synthesis of tricyclic heterocycles via a tandem aryl alkylation/heck coupling sequence”.
J Org Chem. 2007 Feb 26;72(3):775-81.
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Abstract
A norbornene-mediated palladium-catalyzed sequence is described in which two alkyl-aryl bonds and one alkenyl-aryl bond are formed in one pot with use of microwave irradiation. A variety of symmetrical and unsymmetrical oxygen-, nitrogen-, silicon-, and sulfur-containing tricyclic heterocycles were synthesized from a Heck acceptor and an aryl iodide containing two tethered alkyl halides. This approach was further applied to the synthesis of a tricyclic mescaline analogue.
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