Erowid References Database
“The influence of dopaminergic agents on the serotoninergic neurons”.
Pol J Pharmacol Pharm. 1975 Oct 30;27(Suppl):45-6.
The influence of dopaxninergic agents on serotoninergic neurons is presented.
Apomorphine (AP), 1,3-dimethyl- 5-aminoadamantane (DMAA) and piribedil (PB) all induce behavioral excitation, possess antineuroleptic properties and induce hypotension which is not altered by atropine, F-blockers and antihistamines but is antagonized by spiroperidol. PB affects noradrenaline neurons but AP and D_xIA_A do not. AP increases brain 5-HT and 5-HIAA levels, increases the disappearance rate of 5-HT and intensifies the 5-HT fluorescence in the raphe nuclei. DMAA reduces 5-HT levels, increases 5-HIAA levels, reduces fluorescence of 5-HT and does not aflect the rate of disappearance of 5-HT. PB induces slight increases in 5-HT and 5-HIAA levels and does not affect fluorescence of 5-HT. AP, DMAA and PB all inhibit ponto-geniculooccipitalis bioelectrical activity induced in cats by Ro4-1Z48. The dopaminergic agents induce hypothermia in rats and mice similarly to L-dopa (after inhibition of peripheral decarboxylase). DA blockers antagonize the hypothermic effects of dopaininergic agents in rabbits but not that of L-dopa. The hypotherinic effect of AP or L-dopa is attenuated by raphe nuclei lesions but is unaffected by atropine. LSD antagonizes increases of 5-HIAA induced by AP or L-dopa and the hypothermic effects of these agents. AP, DIN_AA and PB induce hypothermia in rabbits, p-Chlorophenylalanine and pimozide antagonize this effect of AP. Locomotor stimulation induced by amphetamine or AP iS intensified by raphe nuclei lesions or p-chloroamphetamine.
Agents which stimulate DA receptors may influence secondarily 5-HT neurons and thus the interaction between dopaminergic and serotoninergic systems would exist. This may be of significance for different pharmacological effects seen after administration of dopaminergic agents
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