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Ishida, J., Wang, H.K., Bastow, K.F., Hu, C.Q., and Lee, K.H.. 
“Antitumor Agents 201 Cytotoxicity of Harmine and B-Carboline Analogs”. 
Bioorganic & Medicinal Chemistry Letters. 1999;? (9):3319-24.
Abstract
Twenty-six B-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. a-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED₅₀ values from 0.3-1.2 ug/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
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