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Mulvena, D.P. and Slaytor M.. 
“N-Methyltransferase Activites in Phalaris Aquatic”. 
Phytochemistry. 1983;22(1):47-8.
The major alkaloids in 7-day-old seedlings of Phalaris aquatica are N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine and gramme Chromatographic evidence indicates that intermediates in the biosynthesis of the alkaloids are present. These intermediates include tryptamine and N-methyltlryptamine in N,N-dimethyltryptamine synthesis, 5-methoxytryptamine and 5-methoxy-N-methyltryptamine in 5-methoxy-N,N-dimethyltryptamine synthesis and 3-aminomethyhlindoIe and 3-methylaminomethylindole in gramme synthesis. Two types of N-methyltransferase activities are present in crude extracts. The first, consisting of two enzyme activities, is involved in the synthesis of N.N-dimethyl- and 5-methoxy-N,N-dimethyltryptamine. Primary indolethylamine N-methyltransferase catalyses the transfer of methyl groups from S-adenosylmethionine to tryptamine and 5-methoxytryptamine, secondary indolethylamine N-methyltransfcrase catalyses the transfer of methyl groups from S-adenosylmethronine to N-methyl and 5-methoxy-N-methyltryptamine, The second, gramme-type N-methyltransferase, catalyses the methylation of 3- amino- and 3-methylaminomethylindole, this being a different enzyme from either primary or secondary indolethylamine N-methyltransferase.
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