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Gallimberti L, Schifano F, Forza G, Miconi L, Ferrara SD. 
“Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal”. 
Eur Arch Psychiatry Clin Neurosci. 1994;244(3):113-4.
This paper describes the role of gamma-hydroxybutyric acid (GHB) in the treatment of opiate withdrawal syndrome. In the two patients described, after having abruptly withdrawn from long-term methadone treatment, GHB was orally administered (each dose given every 4-6 h) for 8-9 days. The GHB showed both a high efficacy (some mild and transient symptoms attributable to opiate withdrawal were observed, but only in the first days of therapy) and a good tolerability (no clinical phenomena interpreted as GHB side effects were found). These results could be of interest in improving the pharmacological treatment of drug addiction.
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