Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Barnett G, Hawks R, Resnick R. 
“Cocaine pharmacokinetics in humans”. 
J Ethnopharmacol. 1981 Mar-May 20;3(2-3):353-66.
Cocaine was given by intravenous administration to human subjects and the concentrations in plasma were measured by gas chromatography--mass spectrometry. Many pharmacokinetic parameters were found to have a strong dose dependence over the range 1 - 3 mg/kg. The terminal plasma half-life in minutes is given by the equation t1/2(beta) = 13.5 + 24.5 dose (r = 0.946). The total plasma clearance in liters/kg per h is 2.51--0.67 dose (r = -0.973). From analysis of previously published data the absorption half-life t1/2(ab) is approximately 8 min for gastrointestinal and for nasal inhalation absorption. The bioavailability for nasal inhalation is approximately 60%. While routes of administration for modern recreational use could lead to unexpected drug accumulation in the blood it is not likely to occur from chewing coca leaves.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]