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Kalra BS. 
“Cytochrome P450 enzyme isoforms and their therapeutic implications: An update”. 
Indian J Med Sci. 2007 Feb;61(2):102-16.
knowledge of and ability to predict drug interactions have improved with growing understanding of substrates, inhibitors and inducers of cytochrome P450 (CYP-450) isoenzymes. These isoenzymes are a major determinant of the pharmacokinetic behavior of numerous drugs. In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease and endogenous chemicals. Prescribing physicians by understanding the unique characteristics of these isoenymes may better anticipate and manage drug drug interactions.
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