Erowid References Database
“Mescaline: the chemistry and pharmacology of its analogs”.
Lloydia. 1973 Mar;36(1):46-58.
Although mescaline (3.4.5-trimethoxyphenethylamine the principal alkaloid of the Peyote plant Lophophora williamsii) has been extensively explored in man as a hallucinogenic intoxicant. only a few of the natural alkaloids that accompany it in nature have been evaluated as chemical individuals. It appears that these congeners do not contribute to the reported action of the intact plant. Synthetic modifications of the structure of mescaline have been more rewarding in the search for relationships between the details of chemical structure and of biological activity. The most thoroughly investigated analogs are the substituted phenylisopropylamines. These carry the carbon skeleton of amphetamine, as is found in natural bases such at ephedrine. Ring substitution arrangements that imitate the peyote alkaloids and the phenylpropenes from the essential oils, have led to a number of hallucinogens generally more potent than mescaline. These all reflect some botanical precedent.
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