Erowid References Database
Westkaemper RB, Glennon RA.
“Molecular Modeling of the Interaction of LSD and Other Hallucinogens With 5-HT2 Receptors”.
NIDA Research Monograph. 1994 Oct;146:263-83.
Multiple populations of serotonin (5-hydroxytryptamine [5-HT]) receptors have been identified, including 5-HT1A, 5-HTlB, 5-HT1c,
5-HT1D, 5-HT2, 5-HT3, and 5-HT4 subtypes. The 5-HT2 and possibly the
5-HT1C receptors have been implicated as the probable sites of action of classical hallucinogenic agents (Glennon 1990). The goal of this chapter is to identify potential modes of interaction of hallucinogens with 5-HT2 receptors.
In general terms, there are two ways to embark on a program designed to elucidate drug-receptor interactions. These have been referred to as the ligand-ligand and ligand-receptor approaches (Westkaemper and Glennon 1991). In the first approach, indirect information about specific receptor structural features and their locations in three dimensions is inferred indirectly from the structures of ligands. Typically, common features of structurally related ligands are graphically superimposed to illustrate common and disparate features that aid formulation of hypotheses related to specific drug-receptor interaction.
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