Erowid References Database
|
Bedford JA, Turner CE, Elsohly HN.
“Comparative lethality of coca and cocaine”.
Pharmacol Biochem Behav. 1982 Nov;17(5):1087-8.
|
|
Abstract
The 24 hour lethal effects of cocaine were compared to those of a crude ethanol extract of the coca leaf (Erthroxylon coca) in male, Swiss mice. Various doses of cocaine HCl and coca leaf extracts suspended in a Tween 60, Arlacel 83, and distilled water vehicle were injected IP into groups of 10 mice. The LD50 for cocaine was 95.1 mg/kg. The LD50 for the coca extract was 3450 mg/kg. The LD50 of the extract based on its cocaine content was 31.4 mg/kg. The results clearly indicate that the coca leaf contains constituents other than cocaine that can contribute to a toxic effect of the plant.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
