Erowid References Database
Nichols CD, Sanders-Bush E.
“Serotonin Receptor Signaling and Hallucinogenic Drug Action”.
The Heffter Review of Psychedelic Research. 2001;2:73-9.
Serotonin, or 5-hydroxytryptamine (5-HT), is a neurotransmitter found in a variety of organisms from the worm to vertebrates. This diverse presence indicates that the serotonergic system is evolutionarily an ancient one.
In lower organisms 5-HT mediates simple behaviors, for example, egg laying in C. elegans (Waggoner et al, 1998). In humans, 5-HT mediates
complex behaviors ranging from sleep and appetite to mood and aggression. Abnormalities in the serotonergic system have been implicated in depression, anorexia and schizophrenia, among others.
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