Erowid References Database
Heinz A, Jones DW.
“Serotonin transporters in ecstasy users”.
Br J Psychiatry. 2000;176:193-5.
Semple et al (1999) report a reduction in vivo of 123I-labelled 2B-carbomethoxy-3B-(4iodophenyl)tropane (B-Cit) update in the cerebral corted of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') users. They interpret this observation to be an indication of a decrease in serotonin transporters in the cortex of MDMA users. However, there are serious methodological concerns with this interpretation of their data.
It has been demonstrated that the radio ligand [123I]B-CIT binds with high affinity to dopamine, serotonin, and noradrenaline transporters in human brain (Farde et al, 1994; Laruelle et all, 1994). In the case of the serotonin transpoter, in vivo displacement of B-CIT binding by selective serotonin reuptake inhibitors (SSRIs) has established that specific (displaceable binding occurs in brainstem and thalamus (Laruelle et al, 1993; Pirker et all, 1995; Tauscher et al, 1999). However this is not true for the cerebral cortex...
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