Erowid References Database
Seiden LS, Fischman MW, Schuster CR.
“Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys”.
Drug Alcohol Depend. 1976 Feb;1(3):215-9.
d-Amphetamine, methamphetamine and other phenethylamines cause decreases in food intake, stereotypic behavior, disruption of behavior that is under stimulus control, as well as general sympathomimetic effects such as hyperthermia, increased blood pressure and piloerection. The doses required to produce different effects vary. In addition, most psychomotor stimulants are subject to abuse in man and will be self-administered by ani- mals . Repeated administration of the amphetamines leads to the devel- opment of tolerance to many of its effects on behavior although the degree of tolerance depends to a large extent on the frequency of administration, the dose, the route of administration and the behavior in question. Several investigators have presented evidence that amphetamines exert their effects upon behavior by increasing the concentration of catecholamines at the synaptic cleft by blocking re-uptake and/or promoting release.
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