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Strassman RJ. 
“Human hallucinogenic drug research: regulatory, clinical, and scientific issues”. 
NIDA Res Monogr. 1994 Oct;146:92-123.
It is likely that no other group of drugs has been subject to such intensive clinical study and to then nearly complete neglect in such a short a period of time as the hallucinogens. Mescaline, the most well-known psychoactive alkaloid of the peyote cactus, was studied in a limited fashion (Kluver 1928) before the discovery of lysergic acid diethylamide (LSD). However, Sandoz Laboratories’ description of the microgram potency of LSD to induce psychotomimetic effects (Stoll 1947) generated tremendous excitement in psychiatry and may be seen as an equally important precursor to the modern era of biological psychiatry, as was the contemporaneous discovery of chlorpromazine’s antipsychotic properties.
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