Erowid References Database
Gouzoulis-Mayfrank E, Thelen B, Maier S, Habermeyer E, Spitzer M, Sass H.
“Modulation of semantic priming effects by psilocybin, MDE (ecstasy) and d-methamphetamine; principles and applicaitons of the model psychosis strategy”.
Neurology Psychiatry and Brain Research. 1998;6:19-28.
Hallucinogenic drug states are useful models for acute episodes of endogenous psychotic disorders. The present article discusses the resemblance of hallucinogen-induced and endogenous psychotic states and summarizes some empirical data on their comparability. The traditional model psychosis strategy offers a valuable tool for investigation of psychosis-related phenomena with modern techniques, and may help to validate basic neurobiological concepts thought to be related to schizophrenia. A number of methodological aspects should be considered in planning modern experimental studies with hallucinogenic drugs. The issue of adequate control substances is discussed in this article, and a recent experimental study of our group on semantic priming effects under psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine is reported. Results suggest an increased availability of remote associations only after ingestion of the hallucinogen psilocybin, but not after ingestion of a [stimulant or ecstasy-like drug. Psilocybin produced a] psychosis with a hyperfrontal metabolic pattern at baseline, but impaired frontal activation upon cognitive demand of a word association task. The implications of these fidnings for schizophrenia research are discussed.
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