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Smith LAC, Meyerson BJ. 
“Influence of Long-term Zimeldine Treatment on LSD-induced Behavioural Effects”. 
Actapharmacol et toxicol. 1984;55:194-198.
The effect of lysergic acid diethylamide (LSD) on copulatory and exploratory behaviour in hormone-treated, ovariectomized rats was investigated 4 weeks aher chronic treatment with either saline or zimeldine (ZIM). A decrease in sensitivity to the lordosis-inhibiting effect of LSD was observed in the group treated with ZIM. The two groups also differed in their reaction to LSD in the exploratory test. The ZIM-treated animals seemed to be less sensitive to LSD. We therefore suggest that long-tenn treatment with ZIM reduces the sensitivity of the postsynaptic serotonin receptor.
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