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Schachter M, Geaney DP, Grahame-Smith DG, Cowen PJ, Elliott JM. 
“Increased platelet membrane [3H]-LSD binding in patients on chronic neuroleptic treatment”. 
Br. J. Clin. Pharmac.. 1985;19:453-457.
1. Using [3H]- lysergic acid diethylamide ( [3H]-LSD) binding techique, platelet 5-hydroxytryptamine (5-HT) receptor number and affinity were compared in schizophrenics treated with depot thioxanthenes and phenothiazines and controls. 2 There was an approximately 30 0ncrease in platelet receptor number (Bmax) in the patient group. 3 There was a decrease in affinity (increase in A) of about 30%, in the patient group. This was probably due to the persistence of the neuroleptic in the platelet membrane preparation. 4 There was a weak positive correlation between receptor number and total neuroleptic dosage. 5 The increased number of 5-HT receptors is consistent with the previously reported enhancement of 5-HT-induced platelet aggregation in patients treated with long-term phenothiazines and thioxanthenes. 6 Our findings are compatible with 5-HT up-regulation in human platelets produced by depot neuroleptic therapy. It is not known whether parallel changes may be occurring in brain 5-HT receptors.
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