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Grillo SA. 
“Effect of dl-amphetamine and d-lysergic acid diethylamide on the slow potentials evoked in the reticular formation”. 
Excerpta Medica. 1981.
A previous report by Morruzi and Magoun (1949) showed that the responses recorded in the reticular formation consisted of a slow potential. However, De Maar et al. (1958) reported 2 types of evoked potentials recorded in the brainstem reticular formation in response to sciatic nerve stimulation in the cat. Grillo (1977) also reported 2 types of evoked potentials, consisting of 'fast' and 'slow' components, in response to auditory stimulus in the cat. Furthermore, an earlier report by Grillo (1968) showed that the slow component was concerned with part of the mechanism responsible for attention and integration of sensory information with regard to its significance. The slow potential was studied under 3 behavior states: awake, drowsiness and sleep. During awakeness, the amplitude of the slow component was found to be appreciably increased when compared with those recorded during the states of drowsiness and sleep. Two drugs, dl-amphetamine and d-lysergic acid diethylamide (LSD-25), which produced desynchronization of the electrocorticogram, were administered intravenously in low doses to the experimental animal. Amphetamine in doses of 0.25 mg/kg significantly increased the amplitude of the slow component of the potential while large doses, 0.75 mg/kg and 1.75 mg/kg respectively decreased the amplitude. LSD-25 in doses of 6 and 15 mcg/kg respectively significantly decreased the amplitude of the slow component. The results lend support to the fact that low doses of amphetamine can increase the level of attention and vigilance while large doses can decrease attention. Furthermore, LSD-25 which shares the same characteristics of electrocorticogram desynchronization with amphetamine appeared to disrupt attention and the effect on the reticular formation auditory evoked potential also lend support to the hallucinogenic effect of this drug.
Notes # : 12th World Congress of Neurology, Kyoto (Japan, Sep 20-25, 1981
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