Plants - Drugs Mind - Spirit Freedom - Law Arts - Culture Library  
Erowid References Database
Nielsen EB, Lee TH, Ellison G. 
“Following Several Days of Continuous Administration d-Amphetamine Acquires Hallucinogenlike Properties”. 
Psychopharmacology. 1980;68(2):197-200.
The effects of chronic amphetamine administration were studied in rats. Methods Female rats (220- 230 g) were implanted with pellets containing 50 mg amphetamine base, of which 26 mg was release in the first 5 days, or with pellets containing polyethylene-glycol vehicle only. All pellets were removed 108 hr after implantation and rats were housed in a soundproof room. 12 Hr later, control rats received i.p. saline, LSD (8 or 25 mcg/kg) mescaline hydrochloride (5 or 10 mg/kg) or amphetamine sulfate (0.3, 1 or 2 mg/kg). Behavior was scored in all rats. Results Rats injected with LSD or mescaline (10 mg/kg) showed behavioral syndrome previously reported to be induced by hallucinogen injection in cat or monkey. Limb flicks or wet dog shakes were not increased over control levels in rats injected acutely with amphetamine. Rats pretreated with slow release amphetamine pellets for 4.5 days and injected with saline 12 he later, were inactive and showed few related behaviors. When similar pellet pretreated rats were injected with amphetamine sulfate (1 mg/kg) prior to testing, they showed a novel behavior syndrome. The number of limb flicks and wet dog shakes increased and there was heightened body grooming. These episodes of intense grooming were different in appearance from that observed at higher stereotypy-inducing doses of amphetamine. Conclusion This syndrome which follows continuous amphetamine administration could serve as an animal model of the type of amphetamine psychosis produced by a similar drug regimen in humans.
Comments and Responses to this Article
Submit Comment
[ Cite HTML ]