Erowid References Database
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Laubscher A, Pletscher A.
“Increase of cyclic GMP in blood platelets by biogenic amines - a receptor-mediated effect”.
J.Pharm.Pharmacol.. 1980;32(8):601-02.
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Abstract
The effect of biogenic amines on cAMP and cGMP levels in human blood platelets was studied. Methods Blood platelets were obtained from healthy donors by dextran gradients. cGMP and cAMP levels were determined by RIA. Platelets were incubated for 3 min with b“ogenic amines at 10-5 to 10-6 M. Results Serotonin (5HT), dopamine (DA), noradrenaline (NA) adrenaline (AD) and psilocin (Sandoz) increased cGMP levels, 5HT and psilocin being the most effective compounds. 5HT Had a maximal effect after 30 sec that lasted for 4 min. cAMP levels were not changed by 5HT or by the catecholamines. Tryptamine, N,N'-dimethyltryptamine and LSD (Sandoz) did not increase cGMP levels. Neither metergoline nor methysergide 10-5 M, reduced the 5HT-induced rise of cGMP. Although butaciamol antagonized the DA-induced increase of cGMP this action was not stereo specific, (+) and (-) butaclamol being equally effective. The actions of (4)- and (-)-NA were similar. Methysergide, chlorpromazine and phentolamine increased cGMP whereas metergoline, spiroperidol and phenoxybenzamine had either no influence or had a lowering effect. Imipramine and amitryptiline either increased or did not change cGMP levels.
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