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Kemali M, Kemali D. 
“Observations On Central Nervous System Structures Following The Administration Of A Psychotomimetic Substance”. 
Acta Neurol.. 1979;34(3):171-176.
The incidental discovery that Lysergic-SaŸre-DiŠthylamid (LSD) is a potent hallucinogenic substance has opened new prospectives in the study of some aspects of mental illnesses The fact that a chemical compound, synthesized in the laboratory, has psychotomimetic effects and has a chemical configuration similar to that of a neurotransmitterŠserotoninŠpresent in the central nervous system, has stimulated several lines of research from behaviour to electrophysiologry and from neurochemistry to psychopharmacology. regarding the effect of this drug on man and on experimental animals. It has been demonstrated that LSD has many sites of action in the central nervous system (on the serotoninergic, nor-adrenergic, dopaminergic systems), but its mechanism of action is still poorly understood (for review see MARTIN and SLOANE, 1977). - The present report describes the effect of the intravenous administration of LSD on the cerebral structures of the frog Raffia esculenta. Frogs were anaesthetized with MS-222 and injected with a single dose of LSD (1 mg/kg in 0.25-ml of distilled water) into a large blood vessel running over the lateral surface of the skull. After periods of survival of 2 and half hours and 7 days, the frogs were fixed by perfusion with a mixture of aldehydes and the dissected brain tissues were post-fixed in osmium tetroxide and observed at the light and electron microscope.
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