Erowid References Database
“Animal models of schizophrenia: the case for LSD-25”.
Schizophrenia Bull.. 1978;4(2):186-209.
Some Difficulties With the Animal Model A recent convergence of ideas which I believe is evident in schizophrenia research suggests that it is worth taking a new look at attemptss that have been and are being made to establish the biological basis of the disorder through the study of an appropriate animal model. Part of the purpose of this paper is to suggest a new strategy. Before the arguments for adopting the strategy to be proposed are presented, however, it is necessary to consider some of the difficulties inherent in trying to erect an animal model of schizophrenia. These are fourfold. First, it is entirely conceivable that schizophrenia is an entirely human condition- a view held by those who consider disorders of language, thinking, and social communicaiton to be essential pathognomonic signs of the disease. If this were so, then the search for an equivalent in lower animals, while not completely fruitless, would be extremely difficult. It is true, as Matthysse and Haber (1975) have recently pointed out, that it might be possible to extract certain nonlinguistic characteristics of schizophrenic thinking which could be studied in animals. Indeed, it might
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