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Tilson HA, Maisel AS, Jourdan MG, Rech RH. 
“Comparison of the Effects of d-Amphetamine and Lysergic Acid Diethylamide in Two Strains of Rats Having Different Behavioral Baselines”. 
Behav. Biology. 1976;17:463-471.
Fisher (F) and Sprague Dawley (SD) rats were trained to press a lever on a fixed interval (F1) schedule of food reinforcement or to postpone electric footshock on an unsignaled, continuous unscheduled avoidance schedule. F strain rats responded on the F1 schedule at a lower rate than the SD rats. Responding of F rats was increased by low doses (0.075-0.10 mg/kg, ip) of d-amphetamine that had no effect on SD rats. However, linear regression analysis of successive quartiles of 1:1 responding indicated little difference between strains in terms of the rate-dependent effects of d-amphetamine (0.075-l.0 mg/kg, ip). In the continuous avoidance procedure, F strain rats had a baseline response rate that was almost twice that of SD rats. However, F strain rats were more sensitive than SD rats to the rate-increasing effects of d-amphetamine (0.1-1.0 mg/kg). Under both schedules of operant responding, SD rats appeared to be more sensitive than rats to the effects of LSD (0.01-0.8 mg/kg, ip). Strain-related differences in sensitivity to the behavioral effects of d-amphetamine and LSD were not predicted from the observed differences in control baseline.
Notes # : Abstract No. 5300
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