Erowid References Database
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Sato M, Sawada M.
“Selective Blocking Action of LSD on Inhibitory Dopamine Receptors”.
Neuropharmacology. 1975;14(11):883-86.
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Abstract
The selective blocking action of D-lysergic acid diethylamide (LSD-25) on inhibitory dopamine receptors is described. Dopamine-induced postsynaptic responses of both excitatory and inhibitory types were recorded from identified neurones of Aplysia ganglion. A 30 sec exposure to 0.1 EM LSD significantly depressed the inhibitory responses to 1 mM dopamine while a 60 sec exposure to 10 mcM LSD did not alter the excitatory response to 0.1 mM dopamine. Dose-response curves obtained from cells with inhibitory receptors indicate that the mode of LSD interaction was non-competitive.
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