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Prozialeck WC, Vogel WH.
“MAO Inhibition and the Effects of Centrally Administered LSD Serotonin, and 5-Methoxytryptamine on the Conditioned Avoidance Response in Rats”.
Psychopharmacology. 1979;60(3):309-10.
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Abstract
The effects of LSD, 5-HT and 5-methoxytryptamine (5-MT) on conditioned avoidance response (CAR) after MAO inhibition was studied. Male Wiatar rats (240-300 g) received chronic cannulae into the right lateral ventricle. Parameters of CAR measured were avoidances, shocks, premature responses (PR), reaction time (latency of avoidance response = RT), and escape time (latency of escape = ET), A )5-trial warm-up period was followed by a 100 trial 'baseline' session. At 10 min after this session, each animal received an intraventricular (i.v.c.) artificial CSF. After 3 min. the animal was subjected to a 100-trial 'control' session. At 10 min after this session, the animal received i.v.c. LSD, 5-HT, or 5-MT dissolved in artificial CSF. After 3 min. the animal was subjected to a 100-trial 'test' aeasion. Other rats received i.v.c. 15 nmoles LSD, 25 nmoles 5-MT, and 25 nmoles 5-HT and were sacrificed after 10 min. LSD was assayed fluorometrically. Results Artificial CSF and 5-HT had no effect on CAR. LSD disrupted CAR, whereas E:T, RT, and PR were not affected. 5-MT caused a less pronounced disruption of the CAR lasting for about 15 min. Following pretreatment with iproniazid, clorgyline, or deprenyl, 5-HT and 5-MT produced a marked disruption of the CAR, with 5-HT also decreasing the number of Pits. Pretreatment with each of the MAO inhibitors, abolished the behavioral effects of LSD. Identical results were obtained when LSD was given i.p. MAO-inhibition did not affect brain LSD, 0.4 + 0.1 mole/ brain were found before, and 0.4 + 0.1 Mole/brain after MAO inhibition. Clorgyline and deprenyl increased brain 5-HT 8.5-fold and 4.4-fold, and of 5-MT 20-fold and 5-fold, respectively.
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