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Kehr W, Speckenbach W. 
“Effect of Lisuride and LSD on Monoamine Synthesis after Axotomy or Reserpine Treatment in Rat Brain”. 
Arch.Pharmacol.. 1978;301(3):163-69.
The effect of lisuride and LSD on catecholamine and serotonin synthesis was studied in axotomized and reserpine-treated rat brain. Methods LSD (Sandoz, 1-1000 mcg/kg, i.p.), lisuride (Cuvalit, Spofa, 1-100 mcg/kg i.p.) and apomorphine (San doz. 100 mcg/kg, i.p.) were given to male Wistar rats (180-220 g) after cerebral hemitransection of the ascending monoaminergic fibers, or 24 hr after reserpine (Serpasil, CIBA-Geigy, 5 mg,7 kg, i.p.). Amino acid decarboxylase was inhibited with 3-hydroxybenzylhydrazine (Sandew 100 mg/kg i.p.) 30 min before the striatum, limbic system and residual cortex were assayed for tyrosine, dopa, tryptophan and 5-hydroxytryptophan by spectrophotofluorimetry. Results LSD (200-1000 mcg/kg) increased dopa and tyrosine formation in the forebrain, but 50 mcg/kg reduced 5-hydroxytryptophan formation. Axotomy increased tyrosine hydroxylation 150%. LSD (500 mcg/kg) reduced the increase in dopa on the lesioned side by 28%, but did not affect the intact side. Haloperidol (Janssen, 2 mg/kg, i.p.), 30 min before section, counteracted the effect of LSD on the lesioned side and increased tyrosine hydroxylation by 1000n the intact side, Lisuride significantly reduced the reserpine-induced increase in dopa formation in the striatum and limbic system and LSD (100 mcg/kg) reduced it in the striatum. Neither was effective in the residual cortex. Apomorphine (100 mcg/kg) reduced dopa formation in the striatum and limbic system of reserpine- treated rats to the same extent as lisuride (100 mcg/kg). LSD (100 g/kg) was less effective. Combination of lisuride and apomorphine was equieffective with either drug alone, but combination of LSD and apomorphine was less effective than apomorphine alone. LSD is a weak dopamine receptor agonist with partial blocking properties whereas lisuride is a potent pure agonist.
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