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Kehr W. 
“Effect of Lisuride and Other Ergot Derivatives on Monoaminergic Neurotransmission in Rat Brain”. 
Arch Pharmacol.. 1977;297(Suppl. 2):R54.
The effects of lisuride hydrogen maleate (L) on monoamine synthesis, turnover and receptor activity were compared with those of LSD, methysergide, yohimbine and methiothepin. The accumulation of dopa and 5-hydroxytryptophan (5-HTP) after inhibition of the aromatic amino acid decarboxylase with NSD 1015 (100 mg/kg i.p.) was used as a measure of catecholamine and 5-hydroxytryptamine (5-HT) synthesis rates. (30-100 mcg/kg) increased dopa formation in the dopamine (DA) rich areas corpus striatum and mesolimbic cortex. In these brain areas L (0.5 ma/ kg) antagonized the stimulation of dope formation induced by cerebral hemitranssection at the level of the caudal hypothalamus and haloperidol effectively counteracted the L-induced decrease in dopa formation on the lesioned as well as on the intact side. The accumulation of 3-methoxytyramine (3-MT) after MAO inhibition with pargyline HC1 (100 mg/kg, i.p.) was used as an indicator of dopamine release. Both, L and LSD (50 ug/kg) reduced 3-MT formation while methysergide (50 mg/kg) had no effect. L increased 5-HT and decreased 5-hydroxyindole acetic acid concentration. All compounds, except methiothepin, reduced 5-HTP accumulation in whole brain. In spinal reserpinized rats L was indistinguishable from LSD in inducing extension and athetoid movements of the hind legs. Conclusions L is a direct agonist on pre- and postsynaptic DA and 5-HT receptors.
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