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Geyer MA, Petersen LR, Rose GJ, Horwitt DD, Light RK, Adams LM, Zook JA, Hawkins RL, Mandell AJ.
“The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: Tactile startle”.
J.Pharmacol.Exp.Ther.. 1978;207(3):837-47.
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Abstract
The effects of lysergic acid diethylamide (LSD) and mescalin derived hallucinogens on sensory integrativ function were studied. Male Sprague-Dawley Rats (200-250 g) were given 1 ml/kg of the salts of the drugs tested i.p. and after 5 min 50-air-puff stimuli were delivered on a 15 sec fixed interval schedule. The startle response (SR) was recorded using a stabilemeter. Results Mescaline (5-20 mg/kg), 0.25-1.0 mg/kg DOM, 0.25-1.0 ma/ kg DOET, 0.125-1.0 mg/kg DOPR, and 0.25-1.0 mg/kg DOBU increased SR; mescaline, DOM, and DGPR producing the largest effects. LSD, N,N-dimethyltryptamine (DMT) and psilocin did not increase tactile SR, at doses comparable to those reported to increase acoustic SR. LSD and DMT had no significant effect at any dose or trial block. At 10 mg/kg, psilocin reduced SR according to Dunnett's test, and also caused hindlimb ataxia but the overall ANOVA was not significant. Clonidine reduced SR in a dose-dependent manner, apomorphine (Merck) increased the response, and d-amphetamine (Sigma), chlorimipramine (Geigy), methysergide maleate (Sandoz), scopolamine (Sigma), methylscopolamine (Sigma) had no significant effect at any of the tested doses. When more intensive air-puffs were used, LSD increased the SR to only the first stimulus, and when the number of stimuli was increased from 60 to 240 in 1 hr. LSD impaired habituation. SR agnitudes of the controls decreased 700ver the session, and of the LSD treated group only decreased by 32%. LSD and phenylethylamine-derived hallucinogens may differ in their effects on tactile SR.
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