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Chadwick D, Hallett M, Jenner P, Marsden CD. 
“5-Hydroxytophan-induced behaviour in guinea-pigs: its relevance to human myoclonus”. 
Brit.J.Clin.Pharmacol.. 1977;4(3):402P-03P.
5-Hydroxytryptophan (5HTP) induced behavior in guinea -pigs was compared to human myoclonus. - Following 5HTP (60 mg/kg s.c. after a-methyl dopahydrazine, 25 mg/kg) in guinea-pigs, jerking occurred synchronously in forelimbs and hindlimbs and displayed a stereotyped electro-myographical pattern of a burst of activity lasting 4050 min. followed by silence lasting 50-70 min and then by a further variable period of muscle activity. EEG recordings showed no change of background activity preceding muscle jerks. 5-HTPinduced jerks were abolished below the level of a spinal cord transection but persisted in decerebrate animals. They could not be involved in cutaneous, visual or auditory stimuli. Jerking identical to 5-HTP-induced behavior was produced by L-tryptophan (200 mg/kg s.c.) following pretreatment with pargyline (75 ma/ kg i.p.) but not by either of these alone. 5-Methoxy-N,N-dimethyltryptamine (5 mg/kg i.p.), quipazine (200 mg/kg i.p.) and lysergic acid diethylamide (0.1-3.2 mg/kg i.p.) produced head and body jerks but were less effective than 5-HTP. 5-HTP-induced jerking was abolished by pretreatment with a central decarboxylase inhibitor NSD 1034 (50 mg/kg i.p.) and by cyproheptadine (510 mg i.p.) and methysergide (5-10 mg/kg i.p.) but not by agents blocking central catecholamine or cholinergic receptors. Conclusion 5-HTP-induced muscle jerking in guinea-pigs does not resemble most forms of human myoclonus.
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