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Svensson TH, Bunney ES, Aghajanian GK. 
“Noradrenergic Regulation of Brain Serotonergic Neurons: Evidence from Single Unit Studies with Clonidine”. 
Pharmacologist. 1974;16(2):244.
Previous studies show that the antihypertensive agent clonidine inhibits noradrenaline (NA) release from peripheral and central adrenergic neurons. The drug also, in mcg-doses, decreases the turnover rate of brain 5-hydroxytryptamine, (5-HT). The effects of clonidine on the firing rates of brain NA neurons were investigated in n. locus coeruleus and serotonergic (5-HT) neurons in n. raphe dorsalis by means of single-cell recording. NA neurons and a majority of 5-HT neurons were inhibited by cionidine (mean dose of 5.7 and 9.0 mcg/kg i.v., respectively). The effect on the 5-HT neurons seemed to be secondary to'the effect on the NA neurons since destruction of the NA input by pretreatment with intraventricularly administered 6 -hydroxydopamine (100 mcg, I wk) abolished the effect of clonidine on the raphe. In contrast, this pretreatment did not antagonize LSD, which inhibits the raphe neurons directly. Also, the NA-releasing drugs, d- or l-amphetamine (0. 5mg/kg i;v.), reversed the effect of clonidine on the raphe. The results support the hypothesis that brain NA neurons may exert a regulatory influence on 5-HT neurons in the raphe .
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