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Kandel D. 
“Stages in Adolescent Involvement in Drug Use”. 
Science. 1975;90:912-914.
Abstract
Two longitudinal surveys based on random samples of high school students in New York State ind icatefour stages in the sequence of involvement with d rugs: beer or wine, or both; cigarettes or hard liquor; marijuana; and other illicit drugs. The legal drugs are necessary intermediates between nonuse and marijuana. Whereas 27 percent of high school sruderls who smoke and drink progress to marihuana within a 5- to 6-month follow-up period, only 2 percent of those who have not used any legal substance do so. Marihuaria, in turn. is a crucial step on the way to other illicit drugs. While 26 percent of marijuana users progress to LSD, amphetamines, or heroin, only I percent of nondrug marihuaria IMers and 4 percent of legal drug users do so. This sequence is found in each of the 4 years in lligil school and in the year after graduation. The reverse sequence holds for regression in drug use.
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