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“The effects of Dextroamphetamine, Dimethyltryptamine, Lysergic Acid Diethylamide and Tetrahydrocannabinol upon Pregnancy and the Offspring”.
Dissertation Abstr Intern B. 1974;34(12):6137B-6138B.
A study was instituted to find out whether dextroamphetamine (DAM), dimethyltryptamine (DMT), lysergic acid diethylamide (LSD) and tetrabydrocannabinol (THC), produced detrimental effects upon the gestation or gestational productivity of Charles River CD(R) strain of rats. The low fertility indices in some subgroups could nbt be attributed to the drugs employed. DMT When given to pregnant rats during organogenesis produced poor reproductivity as shown by embryo absorption, stillborn progeny and small litter size. The agents used had no effect on lactation indices in any of the groups. No gross congenital malformations were found in any offspring from any drug treated group regardless of whether the agents were administered during or prior to pregnancy to either parent. Maternal birthweights were not affected in female animals receiving the drugs. The progeny of female rats receding i.p. or s.c. placebo or drug at a specific time prior to breeding exhibited a diminished ability to learn to lever press for food reward. This finding was the result of a series of stressful situations experienced by the mothers. Progeny of mothers receiving THC and these administered 95% alcohol exhibited a decreased ability to learn to lever press. Progeny of males administered LSD exhibited a decreased ability to learn to lever press. Maternally administered LSD did not pro - duce a postnatal effect upon learning. Those offspring of mothers maternally treated with placebo-(normal saline and olive oil), DAM and DMT showed postnatal decreased ability to learn a fixed - interval discrimination schedule. A difference in discrimination learning between the offspring of the animals maternally adminis - tered THC and the control offspring whose mothers received 95% alcohol Decreased learning of progeny cannot be attributed to drug - dependent decreased motor activity.
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