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Halaris AE, Lovell RA. 
“On the nature of the serotonin binding after LSD.”. 
Fed Proc. 1973;32(3):694.
At.the 57th annual meeting of the Federation of American Societies for Experimental Biology, a study :of the nature of serotonin (5-HT) binding was reported. It was concluded that the enhanced binding of 5-HT after LSD most probably occurs in the synaptic vesicles. To test. this concept, animals were pretreated with reserpine. LSD was administered at 12, 22 and 48- hours after.reser - pine. LSD failed to cause an increase in 5-HT either in whole brain or in any subcellular frac-. tion, provided that the animals were fully reser - pinized. However, it did cause a significant decrease in the elevation of 5-hydroxyindoleacetic acid, which occurs after reserpine alone. These data are interpreted as indicating that the effect of LSD on 5-HT is contingent upon the.availability of intact vesicles and. that these organelles. are the binding site of 5-HT. (Author abstract modified)
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