Erowid References Database
Haigler HJ, Aghajanian GK.
“A comparison of effects of D-lysergic acid diethylamide (LSD) and serotonin on pre- and postsynaptic cells in the serotonin system.”.
Fed Proc. 1973;32(3):303.
At the- 57th annual meeting of the Federation of American Societies for Experimental Biology' a comparison of effects of d-lysergic acid diethylamide (LSD) and serotonin on presynaptic.and postsynaptic cells in.the serotonin system was reported. LSD inhibits the firing of serotonin (5HT) containing neurons in the midbrain raphe nuclei of rats when it is administered in small amounts either. directly (by microiontophoresis) or intravenously. 5HT applied microiontophoretically at low ejection currents to these presynaptic cells is also' inhibitory. Postsynaptic areas include the cortical nucleus of the amygdala, the ventral lateral geniculate, and.the ventral hippocampus. When 5HT was administered microiontophoretically to cells in these areas, inhibition of firing was usually produced at the saline low ejection currents that were effective.in raphe cells. However, microiontophoretic LSD did not inhibit the postsynaptic cells except at ejection current levels much higher than required for: the. presynaptic cells,.nor did it block the inhibition produced by 5HT. Intravenous LSD consistently inhibited raphe cells, but this same low .dose..often. produced an acceleration in the discharge rate of the postsynaptic cells. This acceleration may be due to a release from a tonic inhibitory influence of the raphe on the postsynaptic.cells, suggesting that LSD.in low doses primarily has a presynaptic action in the 5HT system. (Author abstract) ,,
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