Erowid References Database
“Specific pharmacological management of acute toxicity due to psychedelic drugs”.
Arizona Medicine.. 1972;29(12):920-925.
Current views on antidotal treatment of acute poisoning from hallucinogens are presented. Specific pharmacological intervention is efficacious in the management of acute toxicity caused by some hallucinogenic drugs. Basic pharmacological principles indicate an antagonist - agonist paradigm only in a few cases, i.e.,physostigmine -belladonna alkaloids and possibly chlorpromazine hallucinogens (Iysergic acid diethylamide, mescaline, psilocybin, amphetamine types). In general, most acute physiological and psychologi-cal effects of the naturally occurring anticholinergic (belladonna and stramonium) derivatives can be adequately reversed by physostigmine. Chlorpromazin. and other phenothiazines or possibly the benzodiazepine
derivatives (diazepam or chlordiazepoxide) benefit.many cases of toxicity due to amphetamine,. LSD, mescaline, and psilocybin classes of psychomimetics. Until the controversy surrounding the interaction of chlorpromazine and dimethoxymethylamphetamine in man is resolved, acute- toxic reactions elicited by this particular amphetamine derivative might best be managed by a drug' of the benzodiazepine class. No specific antagonists are yet available for central aberrations induced by phencyclidine or the tetrahydrocannabinol derivatives of marijuana. When in doubt, general.procedures of symptomatic control of acute hallucinogenic toxicity may still be the best course of treatment.
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