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Ambache N, Killick SW, Srinivasan V, Zar MA. 
“Effects Of Lysergic Acid Diethylamide On Autonomic Post-ganglionic Transmission”. 
J Physiol. 1975;246:571-593.
Abstract
1. Six sites of all'onolllic post-ganglionic transmission were examined for susceptibility to LSD. Inhibition of transmission by LSD was confined to tile three sympathetic junctions. 2. Inhibition of sympathetic transmission was maximal with short trains of pulses and declined considerably as train length was increased 3. Evidence for a presynaptic mode of action was obtained. This was the predominant effect of LSD in the rat anococcygeus and dog retractor penis because a-adrenoceptor - blocking properties wore feeble or absent; but in dog splenic strips LSD produced marked post-synaptic a-blockade. 4. The presynaptic inhibitory effect of LSD was unrelated to its 5-HT-blocking property because it was not shared by methysergide. Neither was it mediated by prostaglandin release because it was unaltered by indomethacin, which suppresses prostoglandin synthesis. 5. In the rat anococcygeus and dog retractor penis larger doses of LSD induced slow contractions and, as a result of the concurrent block of motor transmission, revealed relaxation responses on transmural stimulation, caused by the excitation of sacral inhibitory fibres present in these muscles. 6. The LSD contractions were due to stýmuilation of post-synaptic a-adrenoceptors because they were abolished by phentolamine or yohimbine but were present as usual in preparations taken from reserpinized animals 7. LSD blocked presynaptic a-adrenoceptors in the cholinergic motor fibres to the longitudinal muscle of the guinea pig ileum.
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