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Rouse LO, Frank DL. 
“Facilitation of Learned Resistance to Audiogenic Seizures in balb/cCrgl Mice by d-LSD-25”. 
Nature. 1974;248:78-81.
The ability of d-LSD-25 to promote habituation to auditory stimulus and terminal convulsive response was studied. Methods Long-term habituation was effected in Balb/cCrgl mice by exposure to subseizure tones 1 - 4 days before challenging to audiogenic seizure with a louder tone. Conditioned inhibition of seizure was performed by flashing a light with the subthreshold tones and when test came presenting it 5 sec before the louder stimulus. Mice (685) were randomly assigned to groups. When primed on day 21 and tested on day 26 the seizure incidence was 88%. The effect of 180 mcg/kg i.p. LSD in the above and in modified conditions was determined by noting the change in seizure rate. Results Activity wheel stress reduced seizure non-significantly. LSD itself had no direct effect on the incidence of response. The effect on long-term habituation was significantly facilitatory (p< 0.001) while conditioned inhibition was also promoted (p< 0.05). The effect on response to light alone or loud tone alone,was unaltered by LSD. These results did not depend on LSD being present during the testing which was performed 24 hr after injection and training. By comparing dose/effect data for mouse and human it was conjectured that a dose facilitating conditioned inhibition of seizure in human epileptics could be as low as 10 mcg whereas 300 mcg might be required to suppress motor seizure directly. To some extent LSD resembles amphetamine in these respects. LSD may be a useful adjunct to current behavioral and electrophysiological procedures used to treat epilepsy-and related disorders.
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