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Malitz S, Esecover H, Wilkens B, Hoch PH. 
“Some Observations on Psilocybin, a New Hallucinogen, in Volunteer Subjects”. 
Comprehensive Psychiatry. 1960 Feb;1(1).
Fourteen student volunteers, 12 men and 2 women aged 20-27 were given 8-36 mg. (average 24 mg.) Psilocybin orally. . The perceptual responses (visual hallucinations in 12, illusions in 9, body image distortions in 10 and temporal distortion in 5 subjects), affective responses (euphoria in 10, anxiety in 9 and depression in 5 subjects), cognitive alterations (impairment in verbalizing thoughts, disorganized thinking, loosening of associations, flight of ideas, inability to abstract) and autonomic responses (pupillary dilation in 14, nausea in 6, dizziness in 6, flushing in 4, abdominal complaints in 3, blood pressure and pulse changes in 3 cases) were qualitatively similar to the responses that were previously observed in subjects given LSD. With Psilocybin, a greater disturbance of thinking was noted in the cognitive sphere; this may be due to dosage or personality differences. . In 4 of 8 cases, the EEG showed increases in alpha frequency (0.5 to 3.0 c.p.s.) . Duration of drug effect: beginning 30-60 minutes after ingestion, peak response in 1 1/2-2 hours, rapid subsidence. A few subjects were symptom-free in 5-6 hours. . Post drug effects: headache 5, drowsiness and lethargy 3, diarrhea 1, depression in the evening of the study 1 subject. . This drug acts like a toxic agent producing autonomic disturbances and as nonspecific psychic stress on the total organism.
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