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Shankaran M, Yamamoto BK, Gudelsky GA. 
“Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum”. 
J Neurochem. 1999 Jun;72(6):2516-22.
The formation of hydroxyl radicals following the systemic administration of 3,4-methylenedioxymeth-amphetamine (MDMA) was studied in the striatum of the rat by quantifying the stable adducts of salicylic acid and D-phenylalanine, namely, 2,3-dihydroxybenzoic acid (2,3-DHBA) and p-tyrosine, respectively. The repeated administration of MDMA produced a sustained increase in the extracellular concentration of 2,3-DHBA and p-tyrosine, extracellular concentration of 2,3-DHBA and p-tyrosine, DHBA was suppressed in rats treated with mazindol, a dopamine uptake inhibitor. Mazindol also attenuated the long-term depletion of serotonin (5-HT) in the striatum produced by MDMA without altering the acute hyperthermic response to MDMA. These results are supportive of the view that MDMA produces a dopamine-dependent increase in the formation of hydroxyl radicals in the striatum that may contribute to the mechanism whereby MDMA produces a long-term depletion of brain 5-HT content.

Key Words: 3,4-Methylenedioxymethamphetamine— Dopamine—Hydroxyl radical—Striatum. J. Neurochem. 72, 2516–2522 (1999).
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