Erowid References Database
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Smith CM, Walaszek EJ.
“Potentiation of Smooth Muscle Stimulants by Lysergic Acid Diethylamide (LSD)”.
Fed. Proc.. 1961;20:165 (Part I).
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Abstract
"We have reported previously that the hallucinogenic properties of LSD are probably not related to its ability to potentiate the stimulatory effect of the neurohumoral polypeptide substance P on the isolated guinea pig ileum. The present study was undertaken to ascertain the mechanism of this potentiation. LSD can inhibit substance P destroying enzyme activity of guinea pig brain but it has no effect on a substance P destroying enzym preparation from guinea pig ileum. Thus it does not seem that the mechanism of the potentiation is due to inhibition of this enzyme. The potentiation was not due to a summation of the stimulatory effects of LSD and substance P. LSD, in conc. of 6.6 x 10-8 and higher, has also been found to potentiate the stimulatory response to acetylcholine. LSD was added to the organ bath 2 minutes before the addition of the agonist and the potentiation was easily reversed by washing the ileum with fresh Tyrode's. Eserine was also capable of potentiating the response of the guinea pig ileum to substance P. LSD inhibits pseudo cholinesterase and it was concluded that LSD possibly potentiates the stimulatory effect of acetylcholine and those of substance P by an inhibition of intestinal pseudo cholinesterase."
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