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Lennard HL, Abramson HA, Hewitt MP. 
“Drugs and social interaction”. 
Neuro-Psychopharmacology. 1959;p625.
Changes in formal characteristics of interaction and communication were studied in "normal" subjects and patients under LSD. The quantitative aspects of verbal output and interaction rate were measured (distribution of verbal activity, frequency and tempo of participation, duration of verbal utterance and direction of communication). . After administration of 50-100 mcg. LSD the average duration of verbal statements decreased in normal subjects and the ratio of patient ("schizophrenia") verbal actions and nonverbal acts increased relative to that of group partners without LSD. Patients lost some of their self-preoccupation and contained more reference to others. . Under phenylotoloxamine the number of statements by normal subjects expressing agreement increased. . Tolerance studies of schizophrenic patients showed that the tolerance sessions were closer to the placebo states than to the LSD sessions. . It is difficult to distinguish the specific drug effect from the effect resulting from altered social relationship. Once a drug was administered a chain effect set in between the person who took the drug and the person with whom he interacts. . Comment: The authors found that normal subjects under LSD solve a problem as a group only if hostility and antagonism of group members to each other is reduced.
Notes # : Proceedings of the 1st International Congress of Neuro-Psychopharmacology, Rome, September 1958
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