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Tissot R. 
“Essai d'interprétation neuro-physiologique et pharmacologique de quelques thérapeutiques psychiatriques modernes”. 
Méd. et Hyg.. 1959;17:443.
Chlorpromazine, reserpine, iproniazid and LSD, at least to some extent, have an indirect effect on the brain i.e. by influencing metabolism or by affecting cerebral serotonin (5-HT) and norepinephrine. In small doses 5-HT has a sedative effect by stimulating the suppressing intralaminar ("recruiting") system of the thalamus and inhibiting the stimulating "reticular" system (formatio reticularis = f.r.) in the mesencephalon. In high doses 5-HT has a stimulating effect. Norepinephrine produces excitation by stimulating the f.r. . LSD increases the excitability of the f.r. in rabbits and inhibits that of the intralaminar recruiting system. It is questionable whether the central efficacy of LSD has any connection with its 5-HT inhibitory effect, since BOL-148 which is a powerful 5-HT antagonist on the isolated uterus has no psychotomimetic effect. Perhaps this depends only on differences between the cerebral and uterine 5-HT receptors. If LSD acts by inhibiting 5-HT, its antagonism to reserpine is easily understandable because its sedative effect is based on the release of small amounts of 5-HT. Then it is also understandable that LSD does not likewise antagonize chlorpromazine since its sedating effect is based on the inhibition of norepinephrine. . (See 608)
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