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Taeschler M, Weidmann H, Cerletti A. 
“Die Wirkung von LSD auf die Reaktionszeiten bei einer bedingten Fluchtreaktion und im Analgesietest”. 
Helv. physiol. pharmacol. Acta. 1960;18:43.
Investigations on the influence of LSD on a conditioned avoidance response of rats and the reaction of mice to painful stimulations. . Conditioned avoidance response of rats in the cage with electrically charged floor: If an acoustic signal is transmitted shortly before a regular electric shock, the animal learns soon to withdraw from the unpleasant stimulation by jumping onto a rod on hearing the acoustic signal. The reaction time (between onset of acoustic signal and jumping on the rod) is after pretreatment with 0.05-0.2 mg/kg LSD significantly shortened. . Reaction of mice to painful stimulation: In the heat radiation test (heat radiation focused on the tail) the time between onset of stimulation and withdrawal of the tail is significantly shortened after 2 mg/kg LSD s.c. In the hotplate test the time between placing the animal on a 53.5 C hotplate and the first signs of pain (licking of the paws etc.) is significantly shortened after 0.5-2.0 mg/kg LSD s.c. LSD (0.5 mg/kg) abolishes the morphine-induced prolongation of reaction time. . This shortening of the reaction time in rats and mice by LSD is due to an increased sensitivity of the central nervous system to sensory stimulation and to an acceleration processing of sensory stimulation.
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