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Hofmann A. 
“Lysergic acid diethylamide and related compounds. Relationship between spatial arrangement and mental effects.”. 
Chemical concepts of psychosis. 1958;p85.
The author and his assistant made personal studies of the mental effects of the stereo-isomers of LSD. . e-LSD: up to 500 mcg orally had no LSD-like effect, over 500 mcg caused very slight drowsiness. . d-iso-LSD: up to 250 mcg had no effect. . e-iso-LSD: up to 500 mcg had no effect, over 500 mcg caused mild nausea. . As both the author and his assistant had previously made a very marked response to 20 mcg LSD, it seems that the 3 stereo-isomers are at least 15 to 30 times less active than LSD. . It is perhaps of significance that of the 4 possible isomers only one - which corresponds to natural lysergic acid - causes pronounced mental effects.
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