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Freedman DX, Aghajanian GK, Ornitz EM, Rosner B. 
“Patterns of tolerance to lysergic acid diethylamide and mescaline in rats.”. 
Science. 1958;127:1173.
Abstract
Trained rats given LSD daily developed tolerance to the behavioral effects of LSD, as evidenced by the time required to climb a rope. The development of tolerance was variable when LSD was given at intervals of 48 hours. No tolerance was observed when LSD was given at intervals of 72 hours. . Tolerance to the behavioral effects of mescaline did not develop as rapidly as that to LSD. . Tolerance to the bradycardic effect of LSD in rats was not observed.
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